What question did this study set out to answer?

The aim is to transition from a skin-based classification of systemic sclerosis to a molecular classification system.

More Than Skin Deep: Moving From a Skin-Based Phenotypic Model to Molecular Classification of Systemic Sclerosis

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The aim is to transition from a skin-based classification of systemic sclerosis to a molecular classification system.
Review of historical classification criteria based on skin fibrosis extent.
Analysis of associations between different forms of systemic sclerosis and related complications.
Identification of molecular biomarkers that differentiate between limited and diffuse cutaneous systemic sclerosis.
Highlighting associations of lcSSc with CREST syndrome and PAH, and dcSSc with ILD and SRC.

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Randomized trial explores molecular classification in systemic sclerosis, indicating a shift from traditional phenotypic models.

Ng et al. (2026) studied this question.

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