Does chronic therapy with cardiac contractility modulation electrical signals affect cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure?
In a canine model of heart failure, chronic CCM therapy normalizes cytoskeletal protein and MMP expression, offering a mechanistic explanation for improved LV function.
CCM therapy normalizes expression of key cytoskeletal proteins and MMPs and may partly explain the improvement in LV function seen in HF following CCM therapy.
Rastogi et al. (Wed,) studied this question.