Why the study?
Does chronic therapy with cardiac contractility modulation electrical signals affect cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure?
Population
Dogs with heart failure
Design
Preclinical
Authors
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Hypothesis-generating in canine HF models; leaves open clinical translation of CCM effects on proteins.
Does chronic therapy with cardiac contractility modulation electrical signals affect cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure?
In a canine model of heart failure, chronic CCM therapy normalizes cytoskeletal protein and MMP expression, offering a mechanistic explanation for improved LV function.
Rastogi et al. (2007) studied this question.
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