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February 21, 2004European Journal of Heart Failure

Long-Term Effects of Non-Excitatory Cardiac Contractility Modulation Electric Signals on the Progression of Heart Failure in Dogs

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Why the study?

Does long-term cardiac contractility modulation (CCM) therapy prevent progressive LV dysfunction and remodeling in a canine model of chronic heart failure?

Population

12 dogs with chronic heart failure produced by multiple sequential intracoronary microembolizations

Comparison

Non-excitatory cardiac contractility modulation… vs Control dogs with heart failure that did not…

Design

Preclinical

Follow-up

3 months

Authors

HMHideaki MoritaMuroran Institute of TechnologyGSGeorge SuzukiHokko Memorial HospitalWHWalid HaddadMayo Clinic in Florida

Discussion

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Implication

CCM may attenuate remodeling in experimental HF; leaves open translation to patients.

Structured PICO

Does long-term cardiac contractility modulation (CCM) therapy prevent progressive LV dysfunction and remodeling in a canine model of chronic heart failure?

P
Population
12 dogs with chronic heart failure produced by multiple sequential intracoronary microembolizations
I
Intervention
Non-excitatory cardiac contractility modulation (CCM) electric signals delivered continuously for 6 h daily with an average amplitude of 3.3 V for 3 months via a lead implanted in the distal anterior coronary vein
C
Comparator
Control dogs with heart failure that did not have leads implanted
O
Outcome
Progression of LV dysfunction and remodeling (LV end-diastolic volume, LV end-systolic volume, and ejection fraction) over 3 monthssurrogate

Long-term cardiac contractility modulation (CCM) therapy prevents progressive LV dysfunction and attenuates global LV remodeling in a canine model of chronic heart failure.

Cite This Study

Morita et al. (2004) studied this question.

synapsesocial.com/papers/6a716e1a439bab0cabc392fchttps://doi.org/10.1016/j.ejheart.2003.11.001

Topics

Heart failureHFrEF treatmentEchocardiography
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