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March 15, 2001New England Journal of Medicine497 citationsOpen Access

Appendectomy and Protection against Ulcerative Colitis

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RARoland E. AnderssonLinköping UniversityGOGunnar OlaisonCopenhagen University HospitalCTCurt TyskLinköping University

Key Points

  • To evaluate the relationship between appendectomy and the subsequent risk of ulcerative colitis.
  • Analyzed the effects of appendectomy for inflammatory conditions such as appendicitis and lymphadenitis.
  • Focused on individuals who had surgery before the age of 20 years.
  • Appendectomy for inflammatory conditions is linked to a low risk of developing ulcerative colitis.
  • The protective effect is specifically seen in patients operated on before the age of 20.

Abstract

Appendectomy for an inflammatory condition (appendicitis or lymphadenitis) but not for nonspecific abdominal pain is associated with a low risk of subsequent ulcerative colitis. This inverse relation is limited to patients who undergo surgery before the age of 20 years.

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Cite This Study

Andersson et al. (2001) studied this question.

synapsesocial.com/papers/69d6d224639f29d8dcab364ahttps://doi.org/10.1056/nejm200103153441104
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of appendectomy on the clinical course of ulcerative colitis: a synopsis of the ACCURE randomised controlled trial2025
  2. 2Poster Session II - A285 RISK OF COLECTOMY AFTER APPENDECTOMY IN ESTABLISHED ULCERATIVE COLITIS: A SYSTEMIC REVIEW AND META-ANALYSIS2026
  3. 3Association of appendectomy with disease phenotype and clinical course in Crohn's disease: results from two cohorts2025
  4. 4Childhood appendectomy is linked with higher digestive, respiratory and genitourinary disease risk but lower IBD risk2026
  5. 5Appendectomy and colorectal cancer: a mini review from the perspective of gut microbiota and mucosal immunity2026