Does serum digoxin concentration affect mortality in men with heart failure and LVEF ≤45%?
In men with heart failure and LVEF ≤45%, digoxin therapy may be safest and most effective when serum concentrations are maintained between 0.5 and 0.8 ng/mL.
Our findings demonstrate that higher SDCs were associated with increased mortality and suggest that the effectiveness of digoxin therapy in men with heart failure and a left ventricular ejection fraction of 45% or less may be optimized in the SDC range of 0.5 to 0.8 ng/mL.
Rathore et al. (Wed,) studied this question.
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