February 19, 2003JAMA
Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure
Why the study?
Does serum digoxin concentration affect mortality in men with heart failure and LVEF ≤45%?
Population
Men with heart failure and a left ventricular ejection fraction of 45% or less
Design
Cohort
Authors
Discussion
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Member takes
Implication
Supports cautious SDC monitoring in HF; leaves open need for RCTs to confirm optimal range.
Structured PICO
Does serum digoxin concentration affect mortality in men with heart failure and LVEF ≤45%?
P
Population
Men with heart failure and a left ventricular ejection fraction of 45% or less
I
Intervention
Digoxin therapy (assessed by serum digoxin concentration)
O
Outcome
Mortalityhard clinical
In men with heart failure and LVEF ≤45%, digoxin therapy may be safest and most effective when serum concentrations are maintained between 0.5 and 0.8 ng/mL.
Cite This Study
Rathore et al. (2003) studied this question.