Does the Reynolds Risk Score improve global cardiovascular risk prediction compared to Framingham-based models in a multiethnic women's cohort?
The Reynolds Risk Score provides better calibration and discrimination for cardiovascular risk prediction in women compared to Framingham models, which may impact statin therapy decisions.
The Reynolds Risk Score was better calibrated than the Framingham-based models in this large external validation cohort. The Reynolds score also showed improved discrimination overall and in black and white women. Large differences in risk estimates exist between models, with clinical implications for statin therapy.
Cook et al. (Thu,) studied this question.
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