March 8, 2012Circulation261 citationsOpen Access
View Full PaperComparison of the Framingham and Reynolds Risk Scores for Global Cardiovascular Risk Prediction in the Multiethnic Women's Health Initiative
Structured PICO
Does the Reynolds Risk Score improve global cardiovascular risk prediction compared to Framingham-based models in a multiethnic women's cohort?
P
Population
Women in the Multiethnic Women's Health Initiative cohort (including black and white women)
I
Intervention
Reynolds Risk Score
C
Comparator
Framingham-based models
O
Outcome
Global cardiovascular risk prediction (calibration and discrimination)
The Reynolds Risk Score provides better calibration and discrimination for cardiovascular risk prediction in women compared to Framingham models, which may impact statin therapy decisions.
Abstract
The Reynolds Risk Score was better calibrated than the Framingham-based models in this large external validation cohort. The Reynolds score also showed improved discrimination overall and in black and white women. Large differences in risk estimates exist between models, with clinical implications for statin therapy.