What question did this study set out to answer?

To evaluate the predictive accuracy of the Framingham risk score for coronary heart disease mortality and event rates in a representative cohort of British men.

November 27, 2003BMJOpen Access

Predictive accuracy of the Framingham coronary risk score in British men:prospective cohort study

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Why the study?

Does the Framingham risk score accurately predict 10-year coronary heart disease mortality and events in British men?

Population

6,643 British men aged 40-59 years and free from cardiovascular disease at entry into the British regional…

Comparison

Framingham risk score prediction vs Observed 10-year coronary heart disease…

Design

Cohort

Follow-up

10 years

Authors

PBPeter BrindleGeneral / Preventive / Lipids

Discussion

Member takes

Implication

May warrant caution applying Framingham to UK men to avoid overtreatment; leaves open whether recalibrated scores improve outcomes.

Key Points

To evaluate the predictive accuracy of the Framingham risk score for coronary heart disease mortality and event rates in a representative cohort of British men.
Prospective cohort study evaluating 6,643 British men aged 40-59 years free from cardiovascular disease at baseline across 24 towns in the United Kingdom.
Tracked participants over 10 years to compare observed coronary heart disease mortality and combined fatal or non-fatal event rates against rates predicted by the Framingham risk equation.
Coronary heart disease mortality was observed in 2.8% (95% CI 2.4% to 3.2%) of men compared with 4.1% predicted, representing a 47% relative overestimation (P < 0.0001).
Fatal or non-fatal coronary heart disease events occurred in 10.2% (95% CI 9.5% to 10.9%) of men compared with 16.0% predicted, representing a 57% relative overestimation (P < 0.0001).
Among the 93% of men categorized as low risk (<30% in 10 years) by the Framingham score, 84% of all coronary heart disease deaths and non-fatal events occurred.

Structured PICO

Does the Framingham risk score accurately predict 10-year coronary heart disease mortality and events in British men?

Population

6,643 British men aged 40-59 years and free from cardiovascular disease at entry into the British regional heart study.

Intervention

Framingham risk score prediction

Comparator

Observed 10-year coronary heart disease mortality and event rates

Outcome

Comparison of observed 10 year coronary heart disease mortality and event rates with predicted rates for each individualhard clinical

The Framingham risk score significantly overestimates absolute coronary risk in British men, indicating that unadjusted use may lead to over-treatment in primary prevention.

Cite This Study

Peter Brindle (2003) studied this question.

synapsesocial.com/papers/6a7da3d0c2b228f3e18c96b4 https://doi.org/10.1136/bmj.327.7426.1267

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Predictive accuracy of the Framingham coronary risk score in British men:prospective cohort study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Predictive accuracy of the Framingham coronary risk score in British men:prospective cohort study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider