What question did this study set out to answer?

The research aims to understand the mutual regulation between mTORC1 signaling and lysosomes in cellular metabolism.

April 10, 2026Open Access

The Reciprocal Regulation Between mTORC1 Signaling and Lysosomes

Key Points

The research aims to understand the mutual regulation between mTORC1 signaling and lysosomes in cellular metabolism.
Reviewed molecular mechanisms involved in mTORC1 and lysosome interaction.
Analyzed the role of lysosomes in nutrient and growth factor signaling.
Examined mTORC1's effects on lysosomal biogenesis and function.
Described a feedback loop between mTORC1 and lysosomes affecting cellular metabolism.
Found that dysregulation of this interaction could contribute to various diseases.

Abstract

哺乳动物雷帕霉素靶蛋白复合物1（mammalian/mechanistic target of rapamycin complex 1，mTORC1）信号与溶酶体（lysosome）之间的双向调控机制，是细胞代谢调控领域的核心科学问题。溶酶体不仅是细胞内降解大分子的关键场所，更是重要的信号枢纽。它通过整合营养物质、生长因子等多种上游信号，在时空上精准调控mTORC1的招募与激活，进而协调细胞合成代谢与分解代谢的平衡。与此同时，mTORC1通过多层次的反馈机制精密调控溶酶体的生物发生、酸化状态、空间分布、功能活性及其与自噬过程的关联，形成动态的双向调控回路。本文系统梳理了该双向调控网络的分子机制，并探讨其在病理状态下的失调，以期为相关疾病的机制研究与靶向治疗策略的开发提供新视角。

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Authors

Mengling Wang

Lele Wang

Jiangsu University

Wenxiang Fu

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Scientia Sinica Vitae

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The Reciprocal Regulation Between mTORC1 Signaling and Lysosomes

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