What question did this study set out to answer?

The study aims to investigate a new method for resolving racemic ibuprofen sodium using diastereomeric ionic cocrystallization.

April 10, 2026

Chiral Resolution of Racemic Ibuprofen Sodium via Diastereomeric Ionic Cocrystallization with Proline

Key Points

The study aims to investigate a new method for resolving racemic ibuprofen sodium using diastereomeric ionic cocrystallization.
Utilized proline as a resolution agent
Applied diastereomeric ionic cocrystallization technique
Achieved resolution in a single step
Achieved enantiomeric excess greater than 90%
Successfully separated RS-ibuprofen sodium into its chiral components

Abstract

Diasteriomeric ionic cocrystallization is introduced as a novel crystallization-based resolution tool. RS-Ibuprofen sodium is succesfully resolved using proline as a resolution agent, achieving ee>90% in a single resolution step. This...

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