Research demonstrates effective chiral resolution of ibuprofen sodium in a single step, implying a new crystallization method's potential.
Diasteriomeric ionic cocrystallization is introduced as a novel crystallization-based resolution tool. RS-Ibuprofen sodium is succesfully resolved using proline as a resolution agent, achieving ee>90% in a single resolution step. This...
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Wen et al. (2026) studied this question.
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