Development of Chitosan Nanoparticles for PRPF31 Gene Delivery in the Treatment of Retinitis Pigmentosa

Key Points

• The research aims to develop chitosan nanoparticles for effective gene delivery targeting the PRPF31 gene in retinitis pigmentosa.
• Utilized chitosan as a biocompatible material for nanoparticle formulation.
• Evaluated the delivery efficacy of pDNA within nanoparticles in vitro.
• Assessed the potential for non-viral gene therapy applications.
• Chitosan-pDNA nanoparticles show promise as a delivery vehicle for gene therapy.
• In vitro studies indicate successful gene delivery efficiency.
• Further research in animal models is necessary to explore therapeutic potential.