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April 10, 2026Current Drug Delivery0 citations

Development of Chitosan Nanoparticles for PRPF31 Gene Delivery in the Treatment of Retinitis Pigmentosa

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MJMd Jobair Hossen JonyCreighton UniversityEMErik D. MooreCreighton UniversityADAlekha K. DashCreighton University

Key Points

  • The research aims to develop chitosan nanoparticles for effective gene delivery targeting the PRPF31 gene in retinitis pigmentosa.
  • Utilized chitosan as a biocompatible material for nanoparticle formulation.
  • Evaluated the delivery efficacy of pDNA within nanoparticles in vitro.
  • Assessed the potential for non-viral gene therapy applications.
  • Chitosan-pDNA nanoparticles show promise as a delivery vehicle for gene therapy.
  • In vitro studies indicate successful gene delivery efficiency.
  • Further research in animal models is necessary to explore therapeutic potential.

Abstract

These CS-pDNA NPs may have potential as a non-viral delivery vehicle in gene therapy in RP, however, further research in animal models is needed to validate the in vitro findings and for their potential therapeutic applications.

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Cite This Study

Jony et al. (2026) studied this question.

synapsesocial.com/papers/69d895486c1944d70ce062f0https://doi.org/10.2174/0115672018409641251130113502
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Precision Therapy Approach for Retinitis Pigmentosa 11 Using Splice-Switching Antisense Oligonucleotides to Restore the Open Reading Frame of PRPF312024 · 12 citations
  2. 2Genetic Therapies for Retinitis Pigmentosa: Current Breakthroughs and Future Directions2025 · 7 citations
  3. 3Establishment of CSUASOi014-A, an induced pluripotent stem cell line from blood-derived cells of a Chinese patient carrying PRPF31 gene mutation2026
  4. 4AAV gene therapy rescues photoreceptor degeneration and ciliopathies in retinal organoids of PRPF6-associated retinitis pigmentosa2026
  5. 5Suprachoroidal gene transfer with nonviral nanoparticles in large animal eyes2024 · 21 citations