Does low-intensity warfarin therapy prevent recurrent venous thromboembolism compared to conventional-intensity warfarin therapy in patients requiring long-term prevention?
Conventional-intensity warfarin is superior to low-intensity warfarin for preventing recurrent VTE, as low-intensity therapy is less effective and does not reduce bleeding risk.
Conventional-intensity warfarin therapy is more effective than low-intensity warfarin therapy for the long-term prevention of recurrent venous thromboembolism. The low-intensity warfarin regimen does not reduce the risk of clinically important bleeding.
Kearon et al. (Thu,) studied this question.