Why the study?
Does low-intensity warfarin therapy prevent recurrent venous thromboembolism compared to conventional-intensity warfarin therapy in patients requiring long-term prevention?
Does low-intensity warfarin therapy prevent recurrent venous thromboembolism compared to conventional-intensity warfarin therapy in patients requiring long-term prevention?
Conventional-intensity warfarin is superior to low-intensity warfarin for preventing recurrent VTE, as low-intensity therapy is less effective and does not reduce bleeding risk.
Conventional-intensity warfarin is preferred for long-term VTE prevention; confirms low-intensity is inferior without bleeding benefit.
Conventional-intensity warfarin therapy is more effective than low-intensity warfarin therapy for the long-term prevention of recurrent venous thromboembolism. The low-intensity warfarin regimen does not reduce the risk of clinically important bleeding.
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Kearon et al. (2003) studied this question.
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