Establishing empirically derived non-inferiority margins for large-scale trials: An umbrella review of meta-analytic comparisons of bona fide psychological therapies

Key Points

• The research aims to derive non-inferiority margins that can be applied to large-scale trials of psychological therapies.
• Conducted an umbrella review of meta-analytic studies comparing psychological therapies
• Analyzed existing data to derive generalizable estimates for non-inferiority margins
• Established empirically derived non-inferiority margins applicable to various trials
• Highlighted the need to distinguish between small meaningful effects and negligible outcomes in therapy comparisons