An umbrella review establishes non-inferiority margins in psychological therapies, indicating standards for effect size comparisons.
This study provides empirically derived estimates for non-inferiority margins that are generalizable to large-scale trials to differentiate between small but nuanced effects and negligible non-inferior effects. Research on bona fide psychological therapy that accepts working on small effects needs careful consideration of confounding effects.
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Flückiger et al. (2026) studied this question.
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