What question did this study set out to answer?

Examine factors that lead to concurrent use of benzodiazepines and opioids after total hip and knee arthroplasty.

April 12, 2026Open Access

Factors Associated With Concurrent Benzodiazepine and Opioid Use Following Total Hip and Knee Arthroplasty: A Nationwide Cohort Study

Key Points

Examine factors that lead to concurrent use of benzodiazepines and opioids after total hip and knee arthroplasty.
Nationwide cohort study design
Analysis of preoperative medication use
Assessment of outpatient prescriptions post-surgery
Preoperative benzodiazepine use is the primary factor for concurrent dispensation of benzodiazepines and opioids.
Preoperative use of antidepressants/anxiolytics is also associated with increased concurrent use.

Abstract

Preoperative benzodiazepine use was the main factor associated with new outpatient concurrent benzodiazepine-opioid dispensation after THA/TKA, followed by preoperative antidepressant/anxiolytic use. These results highlighted that careful review of the patient's medication history when planning postoperative pain management could help prevent unsafe co-prescription.

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Cite This Study

Yepes‐Calderón et al. (Wed,) studied this question.

synapsesocial.com/papers/69db37964fe01fead37c5980 https://doi.org/https://doi.org/10.1002/pds.70368

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