Nationwide cohort study reveals that preoperative benzodiazepine use influences new opioid co-prescription after surgery, underscoring the need for careful medication review.
Preoperative benzodiazepine use was the main factor associated with new outpatient concurrent benzodiazepine-opioid dispensation after THA/TKA, followed by preoperative antidepressant/anxiolytic use. These results highlighted that careful review of the patient's medication history when planning postoperative pain management could help prevent unsafe co-prescription.
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Yepes‐Calderón et al. (2026) studied this question.
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