Development of an Integrated Monogenic and Polygenic Risk Assessment Tool for Coronary Artery Disease and Its Application in a Community-Based Health Care Biobank

Key Points

• The goal is to develop a genetic risk assessment tool that integrates monogenic and polygenic factors for coronary artery disease.
• Development of GenProb CAD tool combining monogenic pathogenic variants and polygenic risk scores.
• Application of the tool in community-based health care biobank populations.
• Evaluation of tool effectiveness across diverse genetic backgrounds.
• Improved identification of individuals at high genetic risk for coronary artery disease.
• Demonstrated utility of the risk assessment tool across various populations.