Development of an Integrated Monogenic and Polygenic Risk Assessment Tool for Coronary Artery Disease and Its Application in a Community-Based Health Care Biobank

Jianfeng Xu; Zhuqing Shi; Sumeet A. Khetarpal; Ashley J. Mulford; Osama Siddiqui; Huy Tran; Jun Wei; Annabelle Ashworth; S. Lilly Zheng; David Duggan; Brian T. Helfand; Henry M. Dunnenberger; Peter J. Hulick; David Davidson; Amit V. Khera; Anju Patel; Alan R. Sanders; Arman Qamar

doi:10.1161/circgen.125.005494

Key Points

The goal is to develop a genetic risk assessment tool that integrates monogenic and polygenic factors for coronary artery disease.
Development of GenProb CAD tool combining monogenic pathogenic variants and polygenic risk scores.
Application of the tool in community-based health care biobank populations.
Evaluation of tool effectiveness across diverse genetic backgrounds.
Improved identification of individuals at high genetic risk for coronary artery disease.
Demonstrated utility of the risk assessment tool across various populations.

Abstract

GenProbCAD, a novel integrated genetic risk tool combining monogenic PVs, polygenic risk scores for CAD, and PRSLp(a), improves identification of individuals at high genetic risk for CAD across diverse populations.

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69db380f4fe01fead37c63bb https://doi.org/10.1161/circgen.125.005494

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Development of an Integrated Monogenic and Polygenic Risk Assessment Tool for Coronary Artery Disease and Its Application in a Community-Based Health Care Biobank

Key Points

Abstract

Discussion

Cite This Study

Development of an Integrated Monogenic and Polygenic Risk Assessment Tool for Coronary Artery Disease and Its Application in a Community-Based Health Care Biobank

Key Points

Abstract

Discussion

Cite This Study

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