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June 28, 2026Konuralp Tıp DergisiOpen Access

Beyond Risk Prediction: Polygenic Risk Scores for Coronary Artery Disease and the Realities of Primary Care

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Authors

NIN. Ivanova

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Overview

Review evaluates polygenic risk scores for coronary artery disease, indicating potential for improved primary care decision-making.

Key Points

  • This review examines the role of polygenic risk scores in assessing coronary artery disease risk in primary care settings.
  • Synthesis of genetic basis for coronary artery disease
  • Critical evaluation of polygenic risk scores evidence in primary care
  • Analysis of barriers to implementing risk scores in clinical practice.
  • Polygenic risk scores effectively identify individuals at high risk for coronary artery disease, comparable to monogenic mutations.
  • Clinical implementation is limited by lack of outcome evidence and standardization of action thresholds.
  • PRS may enhance clinical decision-making, but the impact on patient behavior is modest.

Cite This Study

N. Ivanova (2026) studied this question.

synapsesocial.com/papers/6a40bb4561bb0a67205c6d54https://doi.org/10.18521/ktd.1882189
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polygenic Risk Scores and Coronary Artery Disease2025 · 3 citations
  2. 2Polygenic Risk Scores in Cardiovascular Prevention: Clinical Promise, Implementation Challenges, and Genomic Risk Stewardship2026
  3. 3Polygenic risk scores for cardiovascular disease: clinical utility and limitations2026
  4. 4Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care2025 · 1 citations
  5. 5Polygenic risk score for early identification of coronary artery disease in a real-world clinical setting within the Latvian patient population2026