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July 15, 2026CureusOpen Access

Polygenic Risk Scores in Cardiovascular Prevention: Clinical Promise, Implementation Challenges, and Genomic Risk Stewardship

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Authors

HBHamsa J Banjer

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Overview

Narrative review evaluates cardiovascular PRS for preventive care and suggests genomic risk stewardship framework.

Key Points

  • This review aims to assess the potential of polygenic risk scores in enhancing cardiovascular risk assessment and prevention.
  • Focused narrative review of literature on polygenic risk scores and cardiovascular risk.
  • Evaluation of clinical validity of CAD PRS in selected cohorts.
  • Discussion of the implementation challenges and recommendations for genomic risk stewardship.
  • Modest improvements in risk discrimination and reclassification when CAD PRS are added to clinical models.
  • Evident actionability pathway in CAD-focused lipid-lowering primary prevention.
  • Implementation concerns include direct-to-consumer testing, equity, and need for clinician education.

Cite This Study

Hamsa J Banjer (2026) studied this question.

synapsesocial.com/papers/6a5722f088b21df87547fd18https://doi.org/10.7759/cureus.112566
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