Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 27, 2025CardiogeneticsOpen Access

Polygenic Risk Scores and Coronary Artery Disease

View Full Paper
Ask AI
Bookmark
Share

Authors

SASalman AnsariChapman UniversitySLSuvasini LakshmananStanley Medical CollegeMBMatthew J BudoffAlbert Einstein College of Medicine

Discussion

Loading...

Member takes

Overview

Review summarizes the role of polygenic risk scores in genetic risk prediction for coronary artery disease, indicating potential benefits for targeted prevention.

Key Points

  • Individuals with the highest polygenic risk scores have a 3–5-fold higher risk of coronary artery disease.
  • Polygenic risk scores can help reclassify young adults at borderline risk, particularly when combined with coronary artery calcium scoring.
  • Varying consistency in individual polygenic risk score estimates limits their utility across diverse populations.
  • Future research aims to expand multi-ancestry databases to support equitable clinical applications of polygenic risk scores.

Cite This Study

Ansari et al. (2025) studied this question.

synapsesocial.com/papers/68d7cc66eebfec0fc523883dhttps://doi.org/10.3390/cardiogenetics15040027
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beyond Risk Prediction: Polygenic Risk Scores for Coronary Artery Disease and the Realities of Primary Care2026
  2. 2Polygenic Risk Scores in Predicting Coronary Artery Disease in Symptomatic Patients. A Validation Study2024 · 1 citations
  3. 3Polygenic risk scores for cardiovascular disease: clinical utility and limitations2026
  4. 4Polygenic risk score for early identification of coronary artery disease in a real-world clinical setting within the Latvian patient population2026
  5. 5Polygenic Risk Scores in Cardiovascular Prevention: Clinical Promise, Implementation Challenges, and Genomic Risk Stewardship2026