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September 10, 2025Frontiers in GeneticsOpen Access

Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care

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Authors

GNGeorgios NtritsosUniversity of IoanninaEMEfrat Monsonego‐OrnanHebrew University of JerusalemNGNir GamlielOpen University of Israel

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Overview

Pilot study shows polygenic risk score influenced physician management and patient education in coronary artery disease.

Key Points

  • Integration of polygenic risk scores impacted clinical decision-making in 67% of cases, indicating its relevance.
  • Physicians frequently raised patient awareness and offered education, with 73 specific instances noted during consultations.
  • A multicenter, prospective, open-label pilot study involved 150 patients, gathering insights on risk communication strategies.
  • Findings suggest potential for enhancing risk communication rather than directly altering pharmacologic management.

Cite This Study

Ntritsos et al. (2025) studied this question.

synapsesocial.com/papers/68c1afc654b1d3bfb60e7a6ehttps://doi.org/10.3389/fgene.2025.1625822
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