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October 12, 2025Open Access

Enhanced Risk Prediction for Coronary Heart Disease by Leveraging Polygenic Risk Score and Clinical Risk Score in the Hypertensive Population

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Authors

SSSiyuan ShenHainan University YWYuquan WangFudan University YHYue‐Qing HuFudan University

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Implication

Observational analysis shows enhanced risk prediction for coronary heart disease with polygenic risk score, indicating better outcomes in hypertensive individuals.

Key Points

Integrating polygenic risk score significantly enhances risk prediction for coronary heart disease.
The best-performing polygenic risk score was linked to a more than 5-fold increased risk of CHD in the hypertensive population.
Adding the polygenic risk score to clinical risk score improved the C-index from 0.72 to 0.74, indicating better accuracy.
The hypertensive population demonstrated the most significant improvements in identifying CHD risk trajectories.

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/68ebc91af2c3e4d8d926e366 https://doi.org/10.20944/preprints202510.0566.v1

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Implication

Observational analysis shows enhanced risk prediction for coronary heart disease with polygenic risk score, indicating better outcomes in hypertensive individuals.

Enhanced Risk Prediction for Coronary Heart Disease by Leveraging Polygenic Risk Score and Clinical Risk Score in the Hypertensive Population

Discussion

Member takes

Implication

Key Points

Cite This Study

Enhanced Risk Prediction for Coronary Heart Disease by Leveraging Polygenic Risk Score and Clinical Risk Score in the Hypertensive Population

Discussion

Member takes

Implication

Key Points

Cite This Study

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