Diet-induced obesity causes l-arginine deficiency and eNOS uncoupling in perivascular adipose tissue, highlighting a potential therapeutic target for obesity-induced vascular disease.
Diet-induced obesity leads to l-arginine deficiency and eNOS uncoupling in PVAT. The combination therapy with l-arginine and arginase inhibitors may represent a novel therapeutic strategy for obesity-induced vascular disease.
Xia et al. (Wed,) studied this question.