Diet-induced obesity causes l-arginine deficiency and eNOS uncoupling in perivascular adipose tissue, highlighting a potential therapeutic target for obesity-induced vascular disease.
Suggests a mechanism for obesity-related vascular dysfunction; leaves open whether this pathway is clinically targetable.
Diet-induced obesity leads to l-arginine deficiency and eNOS uncoupling in PVAT. The combination therapy with l-arginine and arginase inhibitors may represent a novel therapeutic strategy for obesity-induced vascular disease.
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Xia et al. (2015) studied this question.
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