What question did this study set out to answer?

The aim is to present ASCLEPIO, a framework that models cellular states and derives therapeutic radiation frequencies for restoring biological coherence.

April 21, 2026Open Access

ASCLEPIO:AFrameworkofTopological Coherence for Biophotonic Thera peutics

Key Points

The aim is to present ASCLEPIO, a framework that models cellular states and derives therapeutic radiation frequencies for restoring biological coherence.
Modeling cellular states as positions in the cyclic group Z/162Z
Classifying states into three regimes: ROF, NRC, BASE3
Calculating therapeutic frequency based on geodesic transitions between state nodes
Therapeutic frequency calculated at approximately 2.16e14 Hz
Model predicts a probability ratio of P_ROF / P_total as ~0.2963
NRC states require a minimum of 9 steps to transition to ROF states

Abstract

ABSTRACTWepresentASCLEPIO (ArchitectureofQuantumCoherenceforBiologicalSystems), aframeworkthatmodels cellular state as a position φ in thecyclicgroupZ/162Zandderives, withoutfreeparameters, theirradiationfrequencies that restore biological coherence. The theoretical foundation is the EGM-162 framework Martinet al. 2026, where Z/162Z classifies every state into three regimes: ROF (maximum coherence, 54 nodes, healthy states), NRC (maximum entropy, 0, 54, 108, disease states) and BASE3 (intermediate regimes). The fundamental coherence frequency is derived directly from universal constants: nuC = nuRydberg x alphafs = 3. 28984e15 Hz / 137. 036 ~= 2. 4007e13 HzThe minimum geodesic transition from any NRC node to any ROF node in Z/162Z is 9 steps, yielding thefundamental therapeutic frequency: fₜherapeutic = 9 x nuC ~= 2. 16e14 Hz (~1. 39 µm, near infrared) The central quantitative prediction — verifiable by biophoton spectrometry — is: PROF / Pₜotal = 48/162 = 8/27 ~= 0. 2963

ASCLEPIO:AFrameworkofTopological Coherence for Biophotonic Thera peutics

Key Points

Abstract

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