ASCLEPIO:AFrameworkofTopological Coherence for Biophotonic Thera peutics

ABSTRACTWepresentASCLEPIO(ArchitectureofQuantumCoherenceforBiologicalSystems), aframeworkthatmodels cellular state as a position φ in thecyclicgroupZ/162Zandderives, withoutfreeparameters, theirradiationfrequencies that restore biological coherence. The theoretical foundation is the EGM-162 framework [Martinet al. 2026], where Z/162Z classifies every state into three regimes: ROF (maximum coherence, 54 nodes,healthy states), NRC (maximum entropy, {0,54,108}, disease states) and BASE3 (intermediate regimes).The fundamental coherence frequency is derived directly from universal constants:nu_C = nu_Rydberg x alpha_fs = 3.28984e15 Hz / 137.036 ~= 2.4007e13 HzThe minimum geodesic transition from any NRC node to any ROF node in Z/162Z is 9 steps, yielding thefundamental therapeutic frequency:f_therapeutic = 9 x nu_C ~= 2.16e14 Hz (~1.39 µm, near infrared)The central quantitative prediction — verifiable by biophoton spectrometry — is:P_ROF / P_total = 48/162 = 8/27 ~= 0.2963