What question did this study set out to answer?

This research aims to explore the integration of CRISPR technology with light control for genome engineering.

April 22, 2026

Cover Picture: Light‐controlled genome engineering based on the CRISPR system (BKCS 4/2026) by Jaekyung Moon, Jaeyi Hahm, Sangwoon Yoon, and Hye Ran Koh

Key Points

This research aims to explore the integration of CRISPR technology with light control for genome engineering.
Review of current literature on CRISPR and optogenetics
Analysis of light-controlled genome regulation techniques
Discussion of applications in gene therapy
Light-controlled CRISPR enables precise regulation of genome and transcriptome activities
Provides a framework for studying complex biological processes
Advances potential therapeutic approaches for genetic disorders

Abstract

The cover image illustrates light‐controlled CRISPR‐based genome regulation strategies. By integrating the programmable DNA/RNA targeting capability of CRISPR with optogenetic control, these approaches enable precise spatiotemporal regulation of genomic and transcriptomic activities, offering powerful tools for studying complex dynamic biological processes and advancing gene therapy. Details are in the review article by Jaekyung Moon, Jaeyi Hahm, Sangwoon Yoon, and Hye Ran Koh . image

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Cover Picture: Light‐controlled genome engineering based on the CRISPR system (BKCS 4/2026) by Jaekyung Moon, Jaeyi Hahm, Sangwoon Yoon, and Hye Ran Koh

Key Points

Abstract

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