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This review demonstrates light-controlled CRISPR-based genome regulation, suggesting innovative tools for gene therapy.
The cover image illustrates light‐controlled CRISPR‐based genome regulation strategies. By integrating the programmable DNA/RNA targeting capability of CRISPR with optogenetic control, these approaches enable precise spatiotemporal regulation of genomic and transcriptomic activities, offering powerful tools for studying complex dynamic biological processes and advancing gene therapy. Details are in the review article by Jaekyung Moon, Jaeyi Hahm, Sangwoon Yoon, and Hye Ran Koh .
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