KIF21B, Ubiquitinated by TRIM3, Exerts Oncogenic Role in T-Cell Acute Lymphoblastic Leukemia by Activating Wnt/β-Catenin Pathway | Synapse
April 24, 2026Open Access
KIF21B, Ubiquitinated by TRIM3, Exerts Oncogenic Role in T-Cell Acute Lymphoblastic Leukemia by Activating Wnt/β-Catenin Pathway
Key Points
This research investigates the role of KIF21B in T-cell acute lymphoblastic leukemia and its molecular pathways.
Analysis of KIF21B ubiquitination by TRIM3
Examination of Wnt/β-catenin pathway activation
Cellular assays to evaluate oncogenic effects
KIF21B was found to be ubiquitinated by TRIM3.
Activation of the Wnt/β-catenin pathway was correlated with increased oncogenic activity.
Inhibition of KIF21B reduced cell proliferation in T-ALL models.
Abstract
Pediatric T-cell acute lymphoblastic leukemia (T-ALL) remains a therapeutic challenge, with approximately 20% of patients experiencing relapse due to a limited understanding of molecular drivers ...