KIF21B, Ubiquitinated by TRIM3, Exerts Oncogenic Role in T-Cell Acute Lymphoblastic Leukemia by Activating Wnt/β-Catenin Pathway

Key Points

• This research investigates the role of KIF21B in T-cell acute lymphoblastic leukemia and its molecular pathways.
• Analysis of KIF21B ubiquitination by TRIM3
• Examination of Wnt/β-catenin pathway activation
• Cellular assays to evaluate oncogenic effects
• KIF21B was found to be ubiquitinated by TRIM3.
• Activation of the Wnt/β-catenin pathway was correlated with increased oncogenic activity.
• Inhibition of KIF21B reduced cell proliferation in T-ALL models.