Connecting dots: Ligand-dependent allostery from protein interaction to gene regulation

Key Points

• The research aims to explore how ligand-dependent allostery affects chromatin targeting and gene networks.
• Conducted genome-wide analysis of RARα:RXR interactions.
• Investigated the impact of ligand binding on protein conformation and signaling pathways.
• Ligand binding significantly reshapes chromatin targeting by RARα:RXR.
• Identified potential pathways for developing innovative therapeutics.