Genome-wide analysis reveals ligand-dependent allostery impacts gene regulation, suggesting new therapeutic strategies.
Biomolecular function emerges from dynamic conformational landscapes and allosteric regulation within modular, multicomponent assemblies. Genome-wide analysis of RARα:RXR shows how ligand-dependent allostery reshapes chromatin targeting and gene networks, highlighting opportunities to tune signaling pathways and design next-generation therapeutics.
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Giorgio Colombo (2026) studied this question.
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