What question did this study set out to answer?

To explore the efficacy of inhaled nitric oxide (iNO) as a bridging therapy for respiratory failure in patients with collagen vascular disease.

April 25, 2026The Journal of Medical Investigation0 citationsOpen Access

Successful treatment for collagen vascular disease-related respiratory failure with inhaled nitric oxide as a bridging therapy:A case report

HSHiroki SatoTokushima University Hospital SSSaki SaijoTokushima University KMKota MiyoshiTokushima University Hospital

Key Points

To explore the efficacy of inhaled nitric oxide (iNO) as a bridging therapy for respiratory failure in patients with collagen vascular disease.
Case report evaluation of inhaled nitric oxide use in a patient with respiratory failure due to collagen vascular disease.
Assessment of oxygenation improvements during iNO treatment before immunosuppressive therapy was effective.
Inhaled nitric oxide improved oxygenation in the patient, delaying the need for ECMO (extracorporeal membrane oxygenation).
Successful bridging until immunosuppressive treatment showed effectiveness in managing underlying conditions.

Abstract

In this case, iNO may have served as a bridging therapy, improving oxygenation until immunosuppressive treatment was effective. iNO may serve as a useful interim measure for avoiding ECMO in collagen vascular disease-associated respiratory failure, particularly when pulmonary hypertension is suspected. J. Med. Invest. 73 : 270-273, February, 2026.

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