Capillary-SERS Sensor Based on Aptamer-Mediated Inhibition of Nanozyme Catalysis for Ultrasensitive Detection of Homocysteine in Serum from Hepatocellular Carcinoma Patients | Synapse
April 25, 2026
Capillary-SERS Sensor Based on Aptamer-Mediated Inhibition of Nanozyme Catalysis for Ultrasensitive Detection of Homocysteine in Serum from Hepatocellular Carcinoma Patients
Key Points
The central aim is to develop a highly sensitive sensor for detecting homocysteine in serum, particularly for liver cancer screening.
Developed a capillary-based SERS sensor
Utilized aptamer-mediated capture of homocysteine
Employed nanozyme catalysis for enhanced sensitivity
Successfully detected homocysteine at ultra-low concentrations
Demonstrated significant accuracy compared to traditional methods
Showed potential for early liver cancer diagnosis through serum analysis
Abstract
Early detection and sensitive monitoring of homocysteine (Hcy) in serum are crucial for liver cancer screening. Here, we developed a capillary-based SERS sensor utilizing aptamer capture of Hcy and the...