Capillary-SERS Sensor Based on Aptamer-Mediated Inhibition of Nanozyme Catalysis for Ultrasensitive Detection of Homocysteine in Serum from Hepatocellular Carcinoma Patients

Key Points

• The central aim is to develop a highly sensitive sensor for detecting homocysteine in serum, particularly for liver cancer screening.
• Developed a capillary-based SERS sensor
• Utilized aptamer-mediated capture of homocysteine
• Employed nanozyme catalysis for enhanced sensitivity
• Successfully detected homocysteine at ultra-low concentrations
• Demonstrated significant accuracy compared to traditional methods
• Showed potential for early liver cancer diagnosis through serum analysis