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January 1, 2025Analytical Methods

A capillary SERS sensor based on CRISPR/Cas13a and DS Au-AgNRs for detecting miRNA-221 in serum of hepatocellular carcinoma patients

Zixun Wang Dong Zhang Yuxuan Wu Xu Ye Yayun Qian Feng-Song Chen

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Key Points

Detection of miRNA-221 in serum indicates potential early diagnosis for hepatocellular carcinoma.
Signal decreased significantly when the target present, showing sensor effectiveness.
Capillary SERS sensor employed CRISPR/Cas13a technology for precise biomarker detection.
Implications may extend to improving diagnostic methods for liver cancer.

Implication

Capillary SERS sensor identifies miRNA-221 in serum, suggesting potential for early hepatocellular carcinoma diagnosis.

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Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6928f0f9a65b730b9ea79947 https://doi.org/10.1039/d5ay01517k

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Catalytic hairpin assembly of trivalent RNA-cleaving DNAzyme junctions regulates circular crRNA for sensitive and accurate CRISPR/Cas12a based liver cirrhosis related MicroRNA analysisOriginal Research · 2026 · 1 citations
2Cas12a Trans-Cleavage of Hairpins Triggers a CHA Cascade for an Ultrasensitive SERS Aptasensor.Original Research · 2026 · 3 citations
3An RCA-CRISPR-Enhanced SERS Platform for Ultrasensitive and Single-Nucleotide-Resolved Detection of Exosomal miRNA-21 in Early Lung Cancer2025 · 23 citations
4A Photoelectrochemical Biosensor Mediated by CRISPR/Cas13a for Direct and Specific Detection of MiRNA-212024 · 10 citations
5CRISPR/Cas13a-Responsive and RNA-Bridged DNA Hydrogel Capillary Sensor for Point-of-Care Detection of RNA2024 · 7 citations

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