What question did this study set out to answer?

This review aims to explore the benefits and challenges of incorporating PSMA PET into prostate cancer management.

April 26, 2026Open Access

Future opportunities and nuances with the use of PSMA PET in prostate cancer (MD PET 1)

AMAlicia K. MorgansDana-Farber Cancer Institute CPChristopher M. PieczonkaSUNY Upstate Medical University EYEvan Y. W. YuUniversity of Washington

Key Points

This review aims to explore the benefits and challenges of incorporating PSMA PET into prostate cancer management.
Review of existing literature on PSMA PET use and its diagnostic performance.
Examination of infrastructure limitations and interpretation inconsistencies affecting PSMA PET utilization.
Assessment of PSMA PET's role in clinical decision-making for various prostate cancer risk groups.
PSMA PET offers superior staging accuracy compared to conventional imaging methods.
Barriers such as lack of standard reporting, insufficient training, and variability in facilities impact scan utilization.
Future integration of AI tools and standardized protocols may enhance the diagnostic consistency of PSMA PET.

Abstract

Imaging with prostate-specific membrane antigen (PSMA) PET has significantly improved prostate cancer staging with superior diagnostic performance compared to conventional methods.Although it is increasingly adopted in clinical practice, several barriers hinder its full integration into routine workflows.This review highlights the existing knowledge gaps, infrastructure limitations, and inconsistencies in interpretation that affect the utility of PSMA PET across healthcare settings.We examine the potential reasons behind variability in scan performance, including scanner design, detector technology, sensitivity, and resolution, as well as the accreditation status of the facilities and reader expertise.We also highlight the inconsistent understanding of PSMA PET ordering practices, particularly among urologists, and the influence of ownership-driven utilization, both of which contribute to underuse and overuse.Radiology reporting that lacks sufficient detail and a shortage of trained nuclear medicine specialists may present additional challenges to effective treatment planning, although diagnostic radiologists also contribute to PET scan interpretation.This review highlights the potential role of standardized reporting protocols, accreditation, expanded education, and integration of AI tools in enhancing diagnostic accuracy and consistency.Additionally, we examine the impact of PSMA PET on clinical decision-making in unfavorable intermediate-, high risk-, and biochemically recurrent prostate cancer, as well as the emerging role of PSMA PET-derived metrics in staging, biopsy guidance, and treatment planning.While PSMA PET has shown value in modifying management strategies, its clinical benefit requires validation through future, prospective, outcome-driven studies.In addition, emerging applications of PSMA PET in non-prostate malignancies hold the potential to transform diagnostic and therapeutic approaches beyond prostate cancer.

اسأل الذكاء الاصطناعي

Bookmark

View Full Paper