Comprehensive multi-omics analysis of left ventricular biopsies identified HFpEF-specific alterations in cardiac metabolism and remodeling occurring independently from obesity.
Observational
Metabolic remodeling, specifically dysregulated glycolysis and TCA cycle changes, contributes to myocardial dysfunction in cardiometabolic HFpEF independently of obesity.
Our findings indicate that metabolic remodeling - particularly dysregulated glycolysis and TCA cycle intermediates changes - contributes to myocardial dysfunction in cardiometabolic HFpEF. Importantly, comprehensive multi-omics analysis of LV EMBs identified HFpEF-specific alterations in cardiac metabolism and remodeling occurring independently from obesity. These insights highlight the interplay between metabolic dysregulation, ECM remodeling, and clinical phenotype in cardiometabolic HFpEF, offering a foundation for targeted metabolic interventions in this syndrome.
Capone et al. (Wed,) conducted a observational in Cardiometabolic HFpEF. Comprehensive multi-omics analysis of left ventricular biopsies identified HFpEF-specific alterations in cardiac metabolism and remodeling occurring independently from obesity.