Key result
Multi-omics analysis of LV biopsies identifies HFpEF-specific metabolic and remodeling alterations independent of obesity.
Observational
Metabolic remodeling, specifically dysregulated glycolysis and TCA cycle changes, contributes to myocardial dysfunction in cardiometabolic HFpEF independently of obesity.
Hypothesis-generating for metabolic and extracellular matrix targets in cardiometabolic HFpEF;.
Our findings indicate that metabolic remodeling - particularly dysregulated glycolysis and TCA cycle intermediates changes - contributes to myocardial dysfunction in cardiometabolic HFpEF. Importantly, comprehensive multi-omics analysis of LV EMBs identified HFpEF-specific alterations in cardiac metabolism and remodeling occurring independently from obesity. These insights highlight the interplay between metabolic dysregulation, ECM remodeling, and clinical phenotype in cardiometabolic HFpEF, offering a foundation for targeted metabolic interventions in this syndrome.
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Capone et al. (2026) conducted an observational in Cardiometabolic HFpEF. Comprehensive multi-omics analysis of left ventricular biopsies identified HFpEF-specific alterations in cardiac metabolism and remodeling occurring independently from obesity.
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