June 16, 2015Open Access

The high-density lipoprotein-adjusted SCORE model worsens SCORE-based risk classification in a contemporary population of 30 824 Europeans: the Copenhagen General Population Study

Structured PICO

Does the SCORE-HDL model improve cardiovascular risk classification compared to the standard SCORE model in a contemporary European population?

Population

30,824 Europeans from the Copenhagen General Population Study

Intervention

High-density lipoprotein-adjusted SCORE model (SCORE-HDL)

Comparator

Standard SCORE model

Outcome

Risk classification and discrimination (measured by Net Reclassification Improvement [NRI])surrogate

The SCORE-HDL model worsens risk classification compared to the standard SCORE model, suggesting it does not add clinical value for risk stratification in this population.

Abstract

SCORE-HDL did not improve discrimination compared with SCORE, but deteriorated risk classification based on NRI. Future guidelines should consider lower decision thresholds and prioritize CVD morbidity and people above age 65.

The high-density lipoprotein-adjusted SCORE model worsens SCORE-based risk classification in a contemporary population of 30 824 Europeans: the Copenhagen General Population Study

Structured PICO

Abstract

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