Why the study?
Does the SCORE-HDL model improve cardiovascular risk classification compared to the standard SCORE model in a contemporary European population?
Does the SCORE-HDL model improve cardiovascular risk classification compared to the standard SCORE model in a contemporary European population?
The SCORE-HDL model worsens risk classification compared to the standard SCORE model, suggesting it does not add clinical value for risk stratification in this population.
No support for SCORE-HDL adoption in European cohorts; leaves open HDL's role in refined or subgroup-specific models.
SCORE-HDL did not improve discrimination compared with SCORE, but deteriorated risk classification based on NRI. Future guidelines should consider lower decision thresholds and prioritize CVD morbidity and people above age 65.
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Mortensen et al. (2015) studied this question.
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