November 11, 2013JAMA Internal Medicine
Myocardial Infarction and Ischemic Heart Disease in Overweight and Obesity With and Without Metabolic Syndrome
Key result
Obesity without metabolic syndrome increased the risk of myocardial infarction compared to normal weight without metabolic syndrome (HR 1.88; 95% CI 1.34-2.63).
Why the study?
Are overweight and obesity associated with increased risk of MI and IHD regardless of the presence of metabolic syndrome?
Population
71,527 individuals from the Copenhagen General Population Study
Comparison
Overweight and obesity with and without… vs Normal weight individuals without metabolic…
Design
Cohort
Follow-up
median 3.6 years
Authors
Discussion
Loading...
Member takes
Implication
Overweight and obesity were associated with higher MI and IHD risk irrespective of metabolic syndrome; leaves open causality and prospective confirmation before practice change.
Study Design
Type
Cohort (n=71,527)
Structured PICO
Are overweight and obesity associated with increased risk of MI and IHD regardless of the presence of metabolic syndrome?
P
Population
71,527 individuals from the Copenhagen General Population Study followed for a median of 3.6 years to assess the risk of incident myocardial infarction and ischemic heart disease.
E
Exposure
Overweight and obesity with and without metabolic syndrome
C
Comparator
Normal weight individuals without metabolic syndrome
O
Outcome
Incident myocardial infarction (MI) and ischemic heart disease (IHD)hard clinical
Main Result
Hazard Ratio: 1.88 (95% CI 1.34–2.63)
Overweight and obesity increase the risk of MI and IHD independently of metabolic syndrome, indicating that BMI is sufficient for identifying this risk.
Cite This Study
Thomsen et al. (2013) conducted a cohort in Myocardial Infarction and Ischemic Heart Disease (n=71,527). Overweight and obesity vs. Normal weight individuals without metabolic syndrome was evaluated on Incident myocardial infarction (HR 1.88, 95% CI 1.34-2.63). Obesity without metabolic syndrome increased the risk of myocardial infarction compared to normal weight without metabolic syndrome (HR 1.88; 95% CI 1.34-2.63).