Objectives: To synthesize the clinical characteristics, management, and outcomes of newborns with aplasia cutis congenita (ACC) type I. Introduction: ACC type I is a rare congenital condition characterized by isolated scalp defects without associated malformations. Evidence is limited and fragmented. Methods: We conducted a systematic review of studies reporting individual-level clinical data, including case reports, case series, and correspondence describing individual patients, following PRISMA guidelines. An additional clinical case was included. Results: Thirty-six studies, including 69 newborns, were analyzed. Most lesions were solitary (84.1%), located on the vertex (61.9%), superficial (55%), and more frequent in males (60.9%). Management was predominantly surgical. Complications were uncommon (21.3%), and outcomes were generally favorable. Conclusion: ACC type I typically presents as an isolated scalp defect with a favorable prognosis. Lesion characteristics and risk of complications should guide management.
Uribe-Cavero et al. (Sun,) studied this question.