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May 3, 2026Sage Open Pediatrics

Clinical Characteristics, Management, and Prognosis of Newborns with Aplasia Cutis Congenita Type I: A Systematic Review and Case Report

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Authors

LULeonardo J. Uribe-CaveroFCFabian A Chavez-EcosMCMarisella Chumán-Sánchez

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Overview

Systematic review highlights favorable outcomes in newborns with aplasia cutis congenita type I, guiding management decisions.

Key Points

  • The aim is to synthesize clinical characteristics, management strategies, and outcomes of newborns with ACC type I.
  • Conducted a systematic review of 36 studies, including case reports and series.
  • Included individual-level clinical data following PRISMA guidelines.
  • Analyzed one additional clinical case.
  • Analyzed data from 69 newborns; most lesions were solitary (84.1%) and primarily located on the vertex (61.9%).
  • Management was mainly surgical, with complications occurring in only 21.3% of cases.
  • Outcomes were generally favorable for affected newborns.

Cite This Study

Uribe-Cavero et al. (2026) studied this question.

synapsesocial.com/papers/69f6e6968071d4f1bdfc748ehttps://doi.org/10.1177/30502225261444806
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Closer Look at Aplasia Cutis Congenita: Understanding a Unique Case2024 · 1 citations
  2. 2Non-surgical management of severe aplasia cutis congenital accompanied by a bone defect – a case study2024
  3. 3A Rare Case of Aplasia Cutis Congenita of the Scalp with Dual Skin Defects in a Non-Syndromic Preterm Newborn2025
  4. 4Surgical management of aplasia cutis congenita of the scalp and skull defect in a resource-limited setting: A case report2026
  5. 5An Extensive Case of Aplasia Cutis Congenita2024 · 2 citations